Thank you Dr T, good advice as always. She only sees her oncologist once every 3 weeks and the oncologist spends part of her week in Boston (that's Boston, Lincolnshire not Massachusets) so she's not easy to get hold of but she does ring Jane if she thinks there is a problem. As expected, today her face is flushed, her ankles are swollen and she's feeling hyperactive. Of course none of this stops her and this afternoon she's gone to an art class.